Perlane

What is Perlane?

Perlane is a safe and natural cosmetic dermal filler that restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as nasolabial folds.

What is Perlane Made of?

Made of hyaluronic acid, a natural substance that already exists in the human body, Perlane is a natural cosemetic dermal filler. The hyaluronic acid in Perlane is a crystal-clear gel called NASHA or Non-Animal Stabilized Hyaluronic Acid. NASHA is completely biocompatible with human hyaluronic acid. Perlane maintains its shape using the body's own moisture. The hyaluronic acid in Perlane is hydrophilic or "water loving." As hyaluronic acid gradually degrades, each molecule binds to more water and over time, the same volume can be maintained with less hyaluronic acid. This ability of hyaluronic acid to bind to water is what helps provide lasting results.

How is Perlane different than other hylauronic acid products?

Unlike rooster-derived hyaluronic acids and bovine collagen products, Perlane is free from animal proteins. This limits any risk of animal-based disease transmissions or development of allergic reactions to animal proteins. Perlane is also different from Restylane in that Perlane is a thicker product that is better for filling larger areas or deeper folds, where Restylane is better for defining fine lines and areas such as the borders of the lips.

How long does Perlane Last?

Perlane is proven to give long lasting results. Studies show Perlane effects last at least six months in most patients. Follow-up treatments are generally scheduled at six months intervals although individual results may vary. Recent studies have noted the ability of Restylane and Perlane to cause the buildup of new collagen, which may result in a longer lasting effect. Each treatment provides a better and better result.

How is Perlane different from Botox?

Perlane is a natural, cosmetic filler. Botox is a drug that blocks nerve transmission and relaxes the underlying muscles. Many patients have been very pleased after receiving treatment with both products.

What should I do prior to treatment?

You should take a few precautions before being treated with Perlane. One week prior to treatment with Perlane, avoid taking St. Johns Wort, high doses of Vitamin E supplements, aspirin, and other non-steroidal anti-inflammatory medications, such as ibuprofen. These agents may increase bruising and bleeding at the injection site. Also, if you have previously suffered from facial cold sores, there is a risk that the needle punctures could contribute to another recurrence.

Perlane is injected directly into the skin in tiny amounts by an ultrafine needle, resulting in minimal discomfort. The procedure is simple and convenient and results are practically instantaneous. To optimize your comfort during the short procedure, your physician may decide to numb the treatment area.

Is Perlane Safe?

Since 1996, over 1.5 million Restylane treatments have been safely administered by dermatologists and plastic surgeons in more than 60 countries. This innovative treatment is now approved in the U.S. for the treatment of facial wrinkles and folds.  Perlane became FDA approved in May, 2007 and has enjoyed a similar safety profile as Restylane. 
Perlane has a highly favorable safety profile. It's composed of Non-Animal Stabilized hyaluronic acid. Hyaluronic acid is a substance found naturally in the human body. Perlane is fully biocompatible. There is limited risk of animal-based disease transmission or development of allergic reactions to animal proteins. No allergy testing is required before use.*

After your treatment, you might have some redness or swelling. This will normally last less than seven days. Sunbathing and cold outdoor activities should be avoided until any redness or swelling have disappeared.  Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin.  You should not use Perlane if you are pregnant, breastfeeding, or under the age of 18.

Precautions

The safety of Perlane for use during pregnancy, in breastfeeding females or in patients under 18 years has not been established.

The safety of Perlane in patients with increased susceptibility to keloid formation and hypertrophic scarring has not been studied. Perlane should not be used in patients with known susceptibility to keloid formation or hypertrophic scarring.

The patient should be informed that he or she should minimize exposure of the treated area to excessive sun and UV lamp exposure and extreme cold weather until any initial swelling and redness has resolved.

If laser treatment, chemical peeling or any other procedure based on active dermal response is considered after treatment with Perlane there is a possible risk of eliciting an inflammatory reaction at the implant site. This also applies if Perlane is administered before the skin has healed completely after such a procedure.

Your healthcare professional should discuss what to do after your treatment. However, be sure to review the information below and discuss any concerns with them.

Post-Treatment Checklist

Please observe the following after treatment with Perlane:

After your treatment, you might have some redness or swelling. This will normally last less than seven days. Sunbathing and cold outdoor activities should be avoided until any redness or swelling disappear.  You shouldn't use Perlane if you are pregnant, breastfeeding, or under the age of 18.
Avoid touching the treated area within six hours following treatment. After that, the area can be gently washed.
If you have previously suffered from facial cold sores, there is a risk that the needle punctures could contribute to another recurrence. Speak to your physician about medications that may minimize a recurrence.
Avoid exercise and alcohol for six hours after your treatment.
Having a follow-up treatment before the product has fully dissipated may enhance the lasting effect. Please be sure to consult your physician about recommendations for touch-up or follow-up treatments.
One week prior to your next treatment with Perlane, avoid taking St. Johns Wort, or high doses of Vitamin E supplements, aspirin, and other non-steroidal anti-inflammatory medications, such as ibuprofen. These agents may increase bruising and bleeding at the injection site.

* Perlane contains trace amounts of gram-positive bacterial proteins and is contraindicated for patients with a history of allergies to such material.

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